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EGF is bioactive but barrier-limited: the molecule does what it does only if it reaches the keratinocyte layer, and standard topical formulations deposit most of it on the stratum corneum where it has no relevant receptor

This poses serious health risks, including allergic reactions, infections (particularly with injectable products), or toxicity from unknown contaminants

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Except for brachytherapy APCs designated as Low Volume APCs and APC 2648, we will continue our policy and use the costs derived from CY 2024 claims data to set the final CY 2026 payment rates for brachytherapy sources

The escalation increments are not equivalent